Can you wire interior speakers like you wire subwoofers?

 

Typically you do not. This would potentially rule out stereo sound if you wire together your left and right speakers together in series or parallel. If you wire front/back speakers together this will mess with your front stage and eliminate the fade option. Normally if you have rear fill you want it at lower level than your front or not have rear fill at all.

But the sky is the limit and it is your system and you can do what you want with it.