I just bought a 2000 Nissan Maxima. the tires needed to be rotated pretty bad, so i just did it. while doing so i found 1 tire to be a diiferent size. 3 are 225 50zR 17's. the other is 225 45 R 17. which is now on the front. will this do any damage to the front wheel drive? and what exactly is the difference?

yes, don't put different size tires on the drive wheels...

drive wheels on the same axle cannot have different sized tires, and AWD vehicles must have the same size tires all around

Thank you! I guess I better go switch em back!

Unless he has LSD it'll be fine.

doesnt matter if its LSD or open diff, even in school youre taught that you can never ever ever have different sized tires on the drive wheel