I just bought some new 6x8's to go in the doors, only problem is i have no idea how to get the door panel off to get to the old speakers. let me know to get the panel off please.

 

Here are the instructions as printed in the Nissan Electronic Service Manual for the '01 Maxima (should apply for all 5th gens):

Front door finisher:
1. Remove inside handle escutcheon.
2. Remove screw securing pull handle, and then remove pull handle.
3. Remove power window switch finisher, then disconnect the connectors.
4. Remove mask securing front door finisher.
5. Remove screw securing front door finisher.
6. Remove clips securing front door finisher.
7. Lift out front door finisher. Disconnect harness connectors.

Rear door finisher:
8. Remove inside handle escutcheon.
9. Remove screw securing pull handle, and then remove pull handle.
10. Remove power window switch finisher, then disconnect the connector.
11. Remove clips securing rear door finisher.
12. Lift out rear door finisher.

Peace.